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Computational
Students Find a Home - Learn how the UC Berkeley students started
the Designated Emphasis.
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Spring
2004 DE Graduate Students
Bioengineering
Nick Fawzi
Gavin Price
Biophysics
Alan Moses
Biostatistics
Annette Molinaro
Computer Science
Sourav Chatterji
Barbara Engelhardt
Amoolya Singh
Electrical Engineering
Colin Dewey
Patrick Flaherty
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Integrative Biology
Hua Chen
Alex Lancaster
John Novembre
Owen Solberg
Mathematics
Nick Eriksson
Molecular & Cell Biology
Derek Chiang
Hunter Fraser
Ed Green
Emily Hare
Liana Lareau
Venky Nandagopal
Daniel Pollard
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Physics
Jarrod Chapman
Nicholas Putnam
Plant & Microbial Biology
Lee Chae
Statistics
Jon McAuliffe
Na Xu
Xiaoyue Zhao
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The Graduate Group in Computational and Genomic Biology provides integrated training in computational and genomic biology by drawing on students with diverse backgrounds and various interests.
This specialization allows tremendous flexibility in course sequences and there are several paths you can take to fulfill DE requirements. Based on background and future interests, students can customize courses to accomplish individual research objectives. Click here to view specific DE Courses and learn more about course requirements.
Below are examples of customized Courses of Study by current graduate students:
PhD in Molecular and Cell Biology
Year One:
- Computer Science 294:
Special Topics-Algorithms in Computational Molecular Biology
- Molecular & Cell Biology 211:
Introduction to Structural Biology and Physical Biochemistry
- Molecular & Cell Biology 240:
Advanced Genetic Analysis
- Molecular & Cell Biology C246:
Topics in Computational Biology and Genomics
- Statistics 141C:
Statistics for Bioinformatics
Year Two:
- Public Health 243A:
Special Topics in Biostatistics
Year Three:
- Computer Science 281:
Introduction to Probabilistic Graphical Models
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Derek Chiang
Mike Eisen Research Group, Molecular & Cell Biology Department
Website: http://rana.lbl.gov/~derek/
"Berkeley is a unique place to be at this genomic era. The opportunities are endless for graduate students interested in computational biology and genomics. The interdisciplinary nature of the Berkeley campus nurtures formation of stimulating and productive collaborations. Graduate students have access to wisdom and advice of world-wide famous statisticians, biologists, computer scientists and many other top researches from other fields."
Research Summary
My research seeks to understand how information governing gene expression changes is encoded in genome sequences. In particular, I focus on the multifactorial nature of transcription regulation in yeast. My work on integrating comparative genomics, chromatin immunoprecipitation, and gene expression data yield computational predictions on transcription factors that may work together at the same promoters. I then design biochemical experiments to test the accuracy of these predictions, and to further our understanding of promoter organizational principles.
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PhD in Molecular and Cell Biology
Year 1:
- Molecular & Cell Biology 200:
Advanced Biochemistry and Molecular Biology
- Molecular & Cell Biology 240:
Advanced Genetics Analysis
- Molecular & Cell Biology 230:
Advanced Developmental Biology
Year 2:
- Engineering 77:
Introduction to Computer Programming for Scientists and Engineers
- Math 1B:
Calculus
- Computer Science 9C:
C for Programmers
- Computer Science 61A:
The Structure and Interpretation of Computer Programs
- Math 55:
Discrete Mathematics
- Computer Science 61B:
Data Structures
Year 3:
- Math 53:
Multivariable Calculus
- Statistics C141:
Statistics for Bioinformatics
Year 4:
- Math 54M:
Linear Algebra and Differential Equations with Computers
- Molecular & Cell Biology 290:
Graduate Seminar-Developmental Biology Seminar
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Ed Green
Steven Brenner Research Group, Department of Plant and Microbial Biology
Website: http://compbio.berkeley.edu
"Life as a grad student at Cal is very stimulating. UC Berkeley is known as one of the scientific epicenters of the world. As my research project has grown and evolved into new areas, I have been able to take advantage of the expertise present on campus in ways I could not have foreseen. For example, when we decided that it would be nice to experimentally verify some of our computational predictions, we did not have to even leave the building to find an expert in the area of RNA processing (Don Rio)."
Research Summary
By analyzing EST sequences, we discovered that alternative splicing frequently generates targets for nonsense-mediated mRNA decay (NMD). This coupling of alternative splicing and NMD may represent a widespread mode of post-transcriptional gene regulation. In collaboration with experimentalists, we are verifying selected targets. In addition to increasing the understanding of how the affected genes are regulated, our results raise important questions about the roles and evolutionary histories of alternative splicing and NMD.
For images, see:
http://compbio.berkeley.edu /people/ed/rust/
http://compbio.berkeley.edu /people/ed/SeqCompEval/
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Sunduz Keles
Mark van der Laan Research Group, Division of Biostatistics
Website: http://www.stat.berkeley.edu/~sunduz
"The campus-wide seminars are not only the best way to get familiar with the most exciting, challenging topics
of computational biology and genomics but also provide means to socialize with fellow students who share similar research interests. Through
these seminars, some of which are organized by the graduate students themselves, students have the opportunity to meet and learn from top
researchers. As someone with mathematical background, I benefit enormously from having friends who are well-trained and among the top for consulting on molecular biology and genomics. Berkeley campus offers an international, stimulating, friendly and fun atmosphere for doing research in computational biology and genomics."
Research Summary
My research primarily concerns applications of statistics to problems in molecular biology and genomics. Such applications involve statistical modeling of high dimensional data, model/feature selection, and variability assessment. In particular, my work centers on developing statistical methods and software for detecting binding sites (regulatory motifs) of DNA binding proteins. My collaborators and I developed two novel statistical methods for detecting regulatory motifs (Keles et al., 2002; Keles et al., 2003). The first method identifies binding sites by utilizing microarray gene expression experiments, whereas the second one provides a supervised search method for regulatory motifs. I am also interested in the analysis of complex data structures such as multivariate and missing data. Recently, I have been working on linking gene expression data to clinical outcomes such as survival by using a locally efficient theory for censored data structures.
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PhD in Biostatistics
Year 1:
- Industrial Engineering 263A,B:
Applied Stochastic Processes I and II
- Statistics 210A,B:
Theoretical Statistics
- Statistics 260:
Topics in Probability and Statistics
- Statistics C261:
Quantitative/Statistical Research Methods in Social Sciences
- Public Health 249:
Biostatistical/Epidemiologic Data Applications
- Public Health 295:
Biostatistics Seminar
- Public Health 243B:
Special Topics in Biostatistics (Causal
- Inference:
theory and applications)
- Public Health 292:
Master of Public Health (M.P.H) Seminar
- Public Health 296:
Special Study (Lab for PH243B)
Year Two:
- Public Health 240:
Risk Research Methods
- Statistics 230:
Linear Models
- Statistics 243:
Introduction to Statistical Computing
- Statistics 296:
Resources for Statistical Computing
- Statistics 260:
Topics in Probability and Statistics
- Public Health 240B:
Biostatistical Methods- Survival Analysis and Casuality
- Public Health 292:
Master of Public Health (M.P.H.) Seminar
- Public Health 295:
Seminars
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Year Three:
- Statistics 241A:
Statistical Learning Theory
- Statistics 241B:
Advanced Topics in Learning and Decision-Making
- Public Health 243A:
Special Topics in Biostatistics: Analysis of Censored Data and Causal Inference
- Molecular and Cell Biology C246:
Special Topics-Topics in Computational Biology and Genomics
Year Four:
- Computer Science 294:
Special topics in Machine Learning
- Public Health 243A:
Special Topics in Biostatistics- Multivariate Statistical
Methods for Computational Biology
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Leor Weinberger
Adam Arkin Research Group, Biophysics Graduate Group
Website: http://gobi.lbl.gov/~leor
Research Summary
My thesis research has 2 components: computational and experimental.. Firstly,
I have developed a novel mathematical model for the design of gene therapy
vectors for HIV-1. I am using this model to engineer HIV-1 gene therapy
vectors in the lab and to optimize their performance. These vectors may
potentially exploit a novel stochastic pathway to HIV-1 post-integration
(proviral) latency. Experimentally testing whether such a stochastic mechanism
can lead to HIV-1 proviral latency constitutes the second component of my
project.
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PHD in Biophysics
Fall Term 1999:
- Math 224A:
Mathematical Methods for the Physical Sciences
- Molecular & Cell Biology 206:
Physical Biochemistry
- Molecular & Cell Biology 218Q:
Structural Biophysics
- Molecular & Cell Biology 292:
Research
Spring Term 2000:
- Mechanical Engineering 213:
Fluid Mechanics of Biological Systems
Physics 299: Research
Fall Term 2000:
- Chemistry 299:
Research for Graduate Students
- Math 195:
Special Topics in Mathematics (genomics)
Spring Term 2001:
- Bioengineering 299:
Individual Study or Research
- Molecular & Cell Biology 218P:
Physical Optics & Crystallography
- Molecular & Cell Biology C114:
Introduction to Comparative Viriology
Summer Session 2001:
- Bioengineering N299:
Individual Study or Research
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Fall term 2001:
- Chemistry 299:
Research for Graduate Students
Spring term 2002:
- Chemistry 299:
Research for Graduate Students
- Molecular & Cell Biology 218Q:
Structural Biophysics
- Molecular & Cell Biology 290:
Graduate Seminar-Transcriptional Regulation AU
Summer session 2002:
- Bioengineering N299:
Individual Study or Research
Fall term 2002:
- Bioengineering 298:
Group studies, Seminars, or Group Research
- Environmental Science, Policy and Management 290:
Special Topics in Environmental Science, Policy and management (hiv)
Spring term 2003:
- Molecular & Cell Biology 290:
Graduate Seminar-Virology
- Molecular & Cell Biology C103:
Bacterial Pathogenesis
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